Following the last baseline behavioral screen the bedding material of the 18 n and the 18 h animals was exchanged with sawdust.
Marble burrying test.
The test exhibits between laboratory methodological differences and demonstrates positive treatment responses to an array of pharmacotherapies creating doubts.
Some strains show decreased burying behaviour.
Since findings reported in the literature indicate that marble burying behavior.
The marble burying test is used to record the number of marbles buried by mice placed in a novel environment.
When put in a cage with marbles mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging while mice with a high degree of anxiety tend to engage in a high degree of digging in.
The marble burying test measures one acute dose of anti anxiety agent for thirty minutes.
Mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging.
This test has some predictive value for anti depressant and or anxiolytic drugs.
It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when.
The marble burying test takes advantage of the proclivity of mice to dig in natural settings e g.
It can be weeks before a noticeable change is observed in patients.
When mice are placed in a novel cage a common response is to show increased digging behavior.
In the present investigation the mb test was applied as previously described broekkamp et al 1986 with respect to the setup for a one zone paradigm with slight modifications.
We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits.
The marble burying task can be used both as an indicator of obsessive compulsive like ocd behavior and or anxiety like behavior.
An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior.
However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents.
The marble burying test is a useful model of both obsessive compulsive like ocd behavior and or anxiety like behavior.
This can be counteracted by coating marbles with substances such as tabasco sauce which will.
The marble burying behavior test is an acute test.
Mice which are placed individually in a cage bury glass marbles that are present in the cage.
